- Introduction (1:1–4)
- Paul’s Concern for Timothy (1:5–14)
- Paul’s Situation (1:15–18)
- Special Instructions to Timothy (ch. 2)
- Call for Endurance (2:1–13)
- Warning about Foolish Controversies (2:14–26)
- Warning about the Last Days (ch. 3)
- Terrible Times (3:1–9)
- Means of Combating Them (3:10–17)
- Paul’s Departing Remarks (4:1–8)
- Charge to Preach the Word (4:1–5)
- Paul’s Victorious Prospect (4:6–8)
- Final Requests, Greetings and Benediction (4:9–22)